The ultimate purpose of our models is to identify new drugs that can treat cancers. We test different drugs and combinations in our models to identify which drugs are most likely to work in patients with the measured molecular alterations.

Examples of Work:

  • Defining PAK1 as a predictor of resistance to PI3 kinase inhibition.
  • Identifying how histone deacetylase inhibitors work in lymphoma patients.

Ongoing work:

  • Screen drug combinations in different cell lines.
  • Measure drug responses in different in vivo models.

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