Defining the alterations that characterize cancers is to model these alterations in different systems to understand their consequences. We use a combination of different models including:
Examples of Work:
- Cell lines that are made from patient tumors. We use genetic engineering and other methods to model genetic alterations.
- Computational network models of genetic mutations.
- Models that combine different gene mutations.
- Humanized mouse models that model both the patient’s immune system and cancer.